Kyle Cassidy, a failed musician, is madly in love with Nikki Duke, the attractive wife of an abusive rock star who is on tour. Nikki passes out and bumps her head after a wild night at the Dukes' Hollywood Hills mansion. Kyle dials 911 in a drug-induced frenzy. When two newly partnered paramedics arrive on the scene, they rouse Nikki, patch up Kyle, and then attempt to rob the pair-a plan that quickly goes awry, sending the group on a dark, hilarious adventure into the Los Angeles night.