The Newton family live in their comfortable house, however there seems to something missing. This"hole" is full of a little puppy, that walks into their home and their lifestyles. Beethoven, as he could be known as, grows into a giant of a dog... that a St Bernard. Doctor Varnick, the local vet includes a dreadful and secret side line, which necessitates plenty of dogs for experiments. Beethoven is really on the physician's list.