Beginning in 19th century England, young nobleman Jonathan Joestar finds himself embroiled in a bitter rivalry with Dio Brando, a low-born kid whom Jonathan's father took under his wing after the death of Dio's father. Dissatisfied with his lot in life, Dio's insatiable desire to rule over all led him to seek the mystical powers of an ancient Aztec stone mask in the possession of the Joestars— a relic that will irrevocably transform Dio and Jonathan's fate for generations to come. Fifty years later, in 1938 New York City, Jonathan's grandson Joseph Joestar must take up his grandfather's mission and master the skills required to remove the stone mask and its enormously powerful makers, the Pillar men, who threaten humanity's very existence.