On his 22nd birthday, Manni discovers mass murder in a pub. People who fled to the Izakaya because of their lives are being pursued by K of the Dracula tribe and Yamada of the Corbin tribe's Neo Vampire tribe. Manami was a prodigal child who was destined to save the Dracula family. Manami, who is set to be captured by K, is brought away to the Yamada of the Corvin of Anti-Dracula, and they are imprisoned in the Tokyo Vampire Hotel, also known as Hotel Requiem, which runs against people. Using this hotel, the Korbin tribes had devised a terrible plan. The goal is to gather a huge number of human young men and women, tell them the world is ending, and then choose to live in this powerful shelter hotel and secure food (human blood) for the rest of my life. What is K's purpose? What happens to Manami? And so the war between humanity, vampires, and neo-vampires starts.